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KMID : 0354719920160040347
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Journal of Korean Diabetes Association
1992 Volume.16 No. 4 p.347 ~ p.352
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A CAse of Insulinoma with Insulin Granules confirmed by Electron Microscope
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마상인
김선민/김휘정/유승박/조준환/김기찬/박정식/이중건/최건필
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Abstract
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Insulinoma is a rare functional islet cell tumor of the pancreas which is characterized by fasting hypoglycemia. The symptoms are incidious in onset and show dramatic relief by oral or intravenous administration of glucose.
A 54-year-old woman resented with intermittent loss of conciousness. In prolonged fasting test, she was severely hypoglycemic. The serum insulin and C-peptide levels were elevated inappropriately.
At surgery a ovoid shaped 1.3×1.1 ㎝ sized mass at tail of pancreas was palpated. Distal pancreatectomy was done
Pathologic examination of the resected pancreas by light microscope, immunohistochemical stain and electron microscope showed the islet cell tumor, glandular pattern, of pancreas.
Insulin-secreating granules with Zn-Insulin crystals surrounded by halo were confirmed by electron microscope.
A brief review of the literature was made.
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KEYWORD
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